LF206-15 Molecular Cell Biology
The module aims to achieve a more in depth understanding of the basics of molecular biology. Students will understand the organisation and complexity of the sequence constitution of chromosomes in both Pro- and Eukaryotes. They will be able to understand how genes are controlled by building on the basics learnt in LF104 Molecules, Cells and Organisms on the nature of transcriptional control. They will be able to place this understanding into the context of chromatin remodelling, and will be introduced into the molecular biology of epigenetics. Students will gain an understanding of the mechanism of other layers of post-transcriptional/translational/post-translational control. They will be introduced into modern molecular methods and how they are used to study modern biological problems.
Understanding the biology of eukaryotic organisms requires knowledge of their organisation and operation at the cellular level. An appreciation of the means by which cells perform their many functions is a prerequisite for detailed study of the underlying biochemistry. This module does not cover the entire range of subjects that could be included under the heading of Cell Biology but concentrates on key areas to illustrate principles and to allow students access to the wider range of information available in modern texts.
- To achieve a thorough understanding the structure and sequence content of both Prokaryotes and Eukaryotes.
- To understand the control of gene expression at multiple layers - from chromosomal context, to expression, to modifications of the product.
- To understand the most recent methodology in the field and the context in which they are used.
In the associated tutorials, which is largely based around original research papers, the students should gain an appreciation of how scientific discoveries are made, and the general principles of scientific research. It will also allow students to follow in detail an investigation of the activity of a particular gene product using recombinant DNA technology.
Students should gain a detailed understanding of the molecular biology which underlies the fundamental cellular processes of:
- The cytoskeleton in cellular structure, function and motility
- Mechanisms controlling cell proliferation and genome stability
- Protein processing in secretory pathway organelles
- Cell death programs in eukaryotic cells
Students are expected to gain a clear appreciation of the principles that underpin current understanding of these processes and also of the experimental approaches by which these have been elucidated.
This is an indicative module outline only to give an indication of the sort of topics that may be covered. Actual sessions held may differ.
Transcription and Post-transcriptional Gene Control
Advanced molecular techniques, microarrays, deep sequencing,
directed reverse genetic techniques.
Translation and translational control.
Post-translational modifications and events
Evolution of the eukaryotic cell
Deregulation of the cell cycle in cancer
Cell death ( necrosis and apoptosis)
By the end of the module, students should be able to:
- Students will understand the organisation and complexity of the sequence constitution of chromosomes in both Prokaryotes and Eukaryotes.
- They will be able to understand how genes are controlled by building on the basics learnt in LF104 on the nature of transcriptional control
- They will be able to place this understanding into the context of chromatin remodelling, and will be introduced into the molecular biology of epigenetics
- Students will gain an understanding of the mechanism of other layers of post-transcriptional/translational/post-translational control
- They will be introduced into modern molecular methods and how they are used to study modern biological problems.
- Students will gain a detailed understanding of the biology that underlies the fundamental cellular processes of such as the control of cellular duplication by cyclin-dependent kinases, the major forms of the cytoskeleton and the process of cell death.
- The principles that underpin the current understanding of these processes and their impact on development and disease form the basis of this module.
Indicative reading list
Lodish Molecular Cell Biology 6th edition 2007
Alberts Molecular Biology of the Cell 5th edition 2007
Students are directed to the current literature for an up-to-date appreciation of developments in
30% of the module marks will involve a laboratory class
Subject specific skills
Understand the structure and sequence content of both Prokaryotes and Eukaryotes
Understand the control of gene expression at multiple layers - from chromosomal context, to expression, to modifications of the product
Self directly learning
critical appraisal of source material
|Warwick Medical School||30%|
|Lectures||20 sessions of 1 hour (9%)|
|Practical classes||3 sessions of 6 hours (8%)|
|Private study||112 hours (50%)|
|Assessment||75 hours (33%)|
Private study description
112 hrs self-study and directed reading
No further costs have been identified for this module.
You do not need to pass all assessment components to pass the module.
Assessment group D
|Molecular Cell Biology Lab||30%||30 hours|
Students will need to develop their own cloning strategy to amplify Actin cDNA from a total RNA library.
|Online Examination||70%||45 hours|
The examination for LF206 will be a 1.5 hr paper in June.
Assessment group R
Re-assessment exam for LF206
Feedback on assessment
Pastoral meetings with personal tutors
This module is Core for:
- Year 2 of UBSA-C700 Undergraduate Biochemistry
- Year 2 of ULFA-C1A2 Undergraduate Biochemistry (MBio)
- Year 2 of ULFA-C702 Undergraduate Biochemistry (with Placement Year)
- Year 2 of ULFA-C1A6 Undergraduate Biochemistry with Industrial Placement (MBio)
- Year 2 of UBSA-3 Undergraduate Biological Sciences
- Year 2 of ULFA-C1A1 Undergraduate Biological Sciences (MBio)
- Year 2 of ULFA-C113 Undergraduate Biological Sciences (with Placement Year)
- Year 2 of ULFA-C1A5 Undergraduate Biological Sciences with Industrial Placement (MBio)
- Year 2 of UBSA-C1B9 Undergraduate Biomedical Science
- Year 2 of ULFA-C1A3 Undergraduate Biomedical Science (MBio)
- Year 2 of ULFA-C1A7 Undergraduate Biomedical Science with Industrial Placement (MBio)
- Year 2 of ULFA-CB18 Undergraduate Biomedical Science with Placement Year