Introductory description

This module provides a foundational introduction to the principles of genetics, genomics, and molecular science. It covers the basic concepts of DNA, genetic inheritance, gene structure and function, and the molecular mechanisms that drive genetic variation. Students will explore how these genetic principles apply to human health, with a particular focus on the role of genomics in understanding complex diseases and hereditary conditions. The technologies and techniques used in modern genetic analysis, such as DNA sequencing, polymerase chain reaction (PCR), and genome-wide association studies (GWAS) will be explored.

Module aims

Outline syllabus

This is an indicative module outline only to give an indication of the sort of topics that may be covered. Actual sessions held may differ.

The module offers an in-depth exploration of the human genome, delving into fundamental concepts such as cell biology, meiosis, and mitosis, along with the structural and functional aspects of chromosomes. It investigates the mechanisms behind numerical and structural chromosomal abnormalities and their implications in genetic disorders. The module emphasises the structure and function of nucleic acids and the importance of understanding inheritance patterns, including autosomal dominant, autosomal recessive, and X-linked disorders. Additionally, it highlights current laboratory techniques used to analyse genetic variation.

Learning outcomes

By the end of the module, students should be able to:

• Demonstrate a comprehensive understanding of nucleic acid and chromosome structure, function, and the molecular mechanisms underlying genetic and genomic alterations.
• Critically evaluate and apply the current nomenclature systems to describe genetic variations within the human genome.
• Apply advanced knowledge of inheritance patterns to assess and interpret Mendelian and non-Mendelian disorders in clinical contexts.
• Assess and critique the design, operation, and analytical performance of laboratory techniques used in genetic and genomic diagnostics, including PCR, sequencing, and chromosomal analysis.
• Describe the partnership of genetics and genomics with other clinical specialisms in the investigation and management of genetic and genomic disorders and the contribution to patient care.

Indicative reading list

Reading lists can be found in Talis

Subject specific skills

1. Gain the ability to analyse and interpret genetic data, including understanding gene structure, function, and the mechanisms of inheritance.
2. Learn to apply the correct nomenclature for describing the human genome.
3. Develop proficiency in various molecular techniques used in genetic analysis, such as PCR, DNA sequencing, and genotyping.

Transferable skills

1. Critical Thinking: Students will develop the ability to critically analyse complex problems, enhancing their decision-making skills.
2. Research Skills: Students will improve their ability to conduct literature reviews and synthesise information from scientific research.
3. Time Management and Organisation: Strong organisational skills through the management of assessment deadlines, useful in both professional and entrepreneurial settings.
4. Effective Communication: Students will enhance their written communication skills.