Introductory description

This module constitutes part of the final-year teaching of the school’s provision of advanced-level microbiology teaching. It builds on key microbiological modules from previous years.

Module Lead: Prof. Vardis Ntoukakis

Module Lecturers: Prof. Miriam Gifford, Dr Mojgan Rabiey, Prof. Vardis Ntoukakis

Module aims

Outline syllabus

This is an indicative module outline only to give an indication of the sort of topics that may be covered. Actual sessions held may differ.

This module will cover the molecular and ecological basis of microbe–host interactions, with a strong focus on how microorganisms sense, regulate, and adapt to their environments. Topics include the regulation of bacterial nitrogen metabolism, ammonia assimilation and nitrogen fixation, as well as the control of phosphorus and iron acquisition. It will also explore key bacterial regulatory systems, including two-component systems, sigma factors, quorum sensing, and biofilm formation. These concepts will be placed in the context of complex microbial communities such as plant and gut microbiomes, examining their location, composition, and functional importance. The module will further address host–microbe interactions through pan-eukaryotic immunity and the diverse ways microbes reprogramme host biology.

Learning outcomes

By the end of the module, students should be able to:

• Critically analyse the regulation, integration, and coordination of macromolecular synthesis during microbial cell cycles
• Evaluate intracellular and extracellular response mechanisms that enable bacteria to sense, respond to and adapt to environmental change.
• Analyse the molecular mechanisms underpinning bacterial motility and taxis, and assess their functional significance for survival and behaviour.
• Critically evaluate the role of two‑component sensing systems in bacterial nutrition, environmental sensing and pathogenesis.
• Analyse the process of sporulation in Bacillus as a model of cellular differentiation in bacteria, integrating regulatory, molecular and developmental perspectives.
• Integrate and interpret molecular and cellular evidence to assess the mechanisms and consequences of bacterial cell–cell interactions.

Indicative reading list

Reading lists can be found in Talis

Subject specific skills

a. Demonstrate a clear understanding of the scientific topic
b. Contain evidence of extended reading and lateral integration of material not covered in the lectures
c. Demonstrate independent thought and deep understanding
d. Specifically answer the set question using information from multiple lectures and sources
e. Be structured and formatted in a way that demonstrates understanding and logical flow
f. Use multiple sources to construct complex scientific arguments and integrating these to build and develop the student's own scientific conclusions.

Transferable skills

1. Critical appraisal of source material
2. Self-directed learning
3. Adult learning