Introductory description

This module covers the replication strategies of important viruses, the diseases these viruses cause, antiviral therapies, diagnosis and vaccination. Viral replication strategies, how viruses reproduce inside our cells, are the cornerstone of all virology. Molecular knowledge of how a particular virus replicates allows the development of methods of diagnosis, prevention and treatment of disease. These aspects of virology, along with how human viruses emerge and evolve, will be taught within the context of pandemic viruses such as influenza, HIV and coronaviruses.

Module aims

Outline syllabus

This is an indicative module outline only to give an indication of the sort of topics that may be covered. Actual sessions held may differ.

This module introduces the fundamental principles of virology, exploring how viruses replicate, evolve, and interact with their hosts. Understanding viruses is critical for public health, as they cause significant human diseases and shape global health responses. The course examines key viral pathogens, including influenza, HIV, and coronaviruses, to illustrate diverse replication strategies, immune evasion mechanisms, and the emergence of new viral threats. It also explores how viral infections are diagnosed, prevented through vaccination, and treated with antiviral therapies. A strong emphasis is placed on the molecular and evolutionary principles underlying virus adaptation and disease progression. In addition to theoretical knowledge, students will develop practical skills in mammalian cell culture, virus infectivity assays, and data analysis.

Learning outcomes

By the end of the module, students should be able to:

• Explain how viruses evade the immune system and adapt within populations.
• Compare the replication strategies of key viruses and their implications.
• Describe methods for diagnosing viral infections and developing vaccines and antiviral therapies.
• Perform aseptic mammalian cell culture and viral infectivity assays.
• Analyse virus growth data and interpret results.

Indicative reading list

Dimmock, N. J., Easton, A. J. and Leppard, K. N. Introduction to Modern Virology, 7th edn. (Wiley-Blackwell, 2016).

Other books to consult:
Collier, L. and Oxford, J. Human Virology, 3rd edn. (Oxford University Press, 2006).

Subject specific skills

Understand the replication strategies of selected important viruses and the similarities and differences between them. Understand how human viruses can emerge from animals and how they evolve in a population. Understand how virus infections can be diagnosed, how vaccines are developed and used to prevent viral infection and disease. Understand different types of antiviral therapy, how they are discovered, developed and trialled.

Transferable skills

Adult learning,
self directed learning,
team based learning
quantitative skills