LF904-40 MBio Research Skills (In House)
This module will provide students with a set of key skills in preparation for careers in Biological Research.
This is an indicative module outline only to give an indication of the sort of topics that may be covered. Actual sessions held may differ.
(i) Data handling:
The taught elements will be delivered in seminar / workshops and online and through video resources. They will then complete the associated worksheets. New sets of materials will be made availble weekly in weeks 3 to 24. Online help will be made available through Moodle and face-to-face support will be available on student visit days through QuBIC.
The following topics will be covered:
The importance of statistics and probability in quantitative life science) research: Introduction and motivation
The nature of measurement: Random and systematic errors; repeatability and reproducibility; detection limits; blank correction; propagation of error
Basic notions of Probability: Events and probabilities; Intersections, unions and independence; Conditional probabilities; Bayes theorem; Combinatorics
Summarising data: Types of data; Exploratory data analysis - Graphical tools, Summary statistics; Common statistical distributions and their properties - Normal distribution (including central limit theorem), Binomial distribution, Poisson distribution; Estimates and confidence intervals – point estimates for Normal, Binomial and Poisson distributions, confidence intervals for the mean and for the difference between two means (including the t-distribution)
Statistical computing: Statistics with spreadsheets such as Excel; Choice of statistical packages - GenStat, R and Minitab
Testing hypotheses: Concept and language; Construction of a simple likelihood ratio test; Student’s t-test for comparing means – one-sample, two-sample, paired sample, power; F-test for comparing variances; Chi-square test for association; non-parametric tests.
Simple analyses of continuous data: From a two-sample t-test to one-way analysis of variance (ANOVA); Finding the best fitting line; Comparison of these approaches
Solving real problems: Integrating a range of simple statistical approaches
The basics of experimental design: Main principles of good experimental design – Replication, Randomisation, Blocking and Representativeness; Separation of plot and treatment structure; Choice of treatments and treatment structure; factorial designs; response surfaces
- Analysing designed experiments: Analysis of Variance (ANOVA) and testing assumptions; Extensions for more complicated designs.
- Relationships between variables: Calibration and regression; Finding the best fitting line; Comparison of regression lines; Multiple linear regression and variable selection methods; Common non-linear regression models
- Modelling counts and proportions - Generalised Linear Models, Log-linear models and Logistic Regression
- Multivariate analysis: Data structure - the basic data matrix; principal component analysis; discriminant analysis, canonical variates analysis and multivariate analysis of variance; principal coordinates and cluster analysis; multidimensional scaling, principal component regression, partial least squares and other multivariate methods
- Statistics in Action: Examples of the real-life application of the statistical methods introduced during the module, and identification of some more advanced methods that might be useful in research projects
(ii) Research skills workshops.
Each student will attend research skills workshops. These will take place in small groups (up to 12 students). On each of the days, each of the students will give a 15 minute presentation of a research paper, which will be followed by a brief group discussion. In addition, students will have further training to write research proposals.
Visit 1 (week 5)
Journal club session 1
Introduction to the research funding system.
Visit 2 (week 15)
Journal club session 2
How to write a grant application.
Visit 3: (week 25)
Journal club session 3
Peer assessment of research proposals sumitted by the students in week 18: Mock funding panel.
(iii) Lab skills: students will receive training in a number of experimental methods that are required in order to complete their research. In order to assess this training, students will submit a piece of reflective writing describing the range of techniques, experimental approaches and other skills that they have learned as part of their industrial placement. Feedback from student supervisors will be considered as part of the marking process
By the end of the module, students should be able to:
- Students will gain practical experience of key lab-based techniques and data handling methods.
- They will learn to design and present research projects.
- They will learn to critically assess research proposals and research papers.
Indicative reading list
Subject specific skills
.1. Lab skills and GLP
2. Data handling and quantitative skills
3. Peer review skills
4. Presentation skills
5. Grant proposal writing
6. Critical appraisal of primary sources
- Presentation skills
- writing skills
- Data handling
- Project management
|Tutorials||9 sessions of 1 hour (2%)|
|Practical classes||10 sessions of 7 hours (18%)|
|Other activity||28 hours (7%)|
|Private study||293 hours (73%)|
Private study description
Distance learning, self-study and preparation of assessments.
Other activity description
Quant Skills and technology enhanced statistics sessions
No further costs have been identified for this module.
You do not need to pass all assessment components to pass the module.
Assessment group D
|Lab book assessment||5%|
|Data handling assessment 1||7%|
|Data handling assessment 2||7%|
|Data handling assessment 3||8%|
|Data handling assessment 4||8%|
|Journal Club presentation 1||5%|
|Journal Club presentation 2||5%|
|Journal Club presentation 3||5%|
|Critical review of x3 research papers||8%|
|Reflective assessment on research proposal||7%|
|Lab skills viva||20%|
Feedback on assessment
Feedback will be provided electronically on each piece of written assessment. Feedback on oral presentations will be given in a one-to-one meeting with the academic running the session. Seminars will be recorded to enable independent assessment by external examiners. The recordings will be made available to students as an additional method of feedback.
This module is Core for:
- Year 4 of ULFA-C1A2 Undergraduate Biochemistry (MBio)
- Year 4 of ULFA-C1A1 Undergraduate Biological Sciences (MBio)
- Year 4 of ULFA-C1A3 Undergraduate Biomedical Science (MBio)
- Year 4 of ULFA-C1A4 Undergraduate Medical Microbiology and Virology (MBio)